This methylation profile is already acquired within the MBL stage3 and remains somewhat stable with time. Having said that, some CLL have intratumor variability in specific locations, which can alter the expression of numerous genes and aid tumor evolution.seventy one Of note, this variability is greater in U-CLL than in https://franciscomudks.full-design.com/5-essential-elements-for-situs-judi-mbl77-74969499