Tramadol does not bind on the mu receptor as much as morphine. In contrast to other opioids, tramadol will not reverse its course entirely pursuing naloxone administration.[five] The analgesic impact is additionally attributed to the antinociceptive impact inside the descending pathway, secondary for the inhibition of serotonin and norepinephrine reuptake.[six] https://seingalf642ova8.wikilowdown.com/user